Transcription factors with Perturb-seq knockdown data for ENSG00000253553. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000253553 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000253553, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:86,931,540–86,932,904 | 1395.5 kb | Distal (>10kb) Multiome HiCAR | 174 | |
| chr8:88,088,067–88,088,905 | 239.3 kb | Distal (>10kb) Multiome | 240 | |
| chr8:88,209,942–88,211,703 | 117.0 kb | Distal (>10kb) Multiome | 200 | |
| chr8:88,320,460–88,320,904 | 6.9 kb | Proximal (<10kb) | 170 | |
| chr8:88,326,744–88,329,127 | 1.1 kb | Proximal (<10kb) Multiome | 581 | |
| chr8:88,591,664–88,592,857 | 264.5 kb | Distal (>10kb) Multiome HiCAR | 253 |
Genomic view of the ENSG00000253553 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.