Transcription factors with Perturb-seq knockdown data for ENSG00000253347. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000253347 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000253347, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,188,797–47,189,938 | 234.1 kb | Distal (>10kb) Multiome | 1050 | |
| chr17:47,253,593–47,254,400 | 169.6 kb | Distal (>10kb) Multiome | 571 | |
| chr17:47,275,398–47,275,943 | 147.9 kb | Distal (>10kb) Multiome | 340 | |
| chr17:47,310,107–47,310,844 | 113.1 kb | Distal (>10kb) Multiome | 92 | |
| chr17:47,323,422–47,324,660 | 99.6 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:47,423,404–47,423,999 | 230 bp | At TSS Multiome | 129 | |
| chr17:47,531,659–47,532,268 | 108.7 kb | Distal (>10kb) Multiome | 159 | |
| chr17:47,648,863–47,650,987 | 226.1 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:47,693,705–47,695,210 | 271.0 kb | Distal (>10kb) Multiome | 619 |
Genomic view of the ENSG00000253347 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.