Transcription factors with Perturb-seq knockdown data for ENSG00000253288. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000253288 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000253288, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:137,019,122–137,019,781 | 1064.1 kb | Distal (>10kb) Multiome HiCAR | 11 | |
| chr8:137,783,423–137,784,157 | 299.9 kb | Distal (>10kb) Multiome | 107 | |
| chr8:137,842,778–137,843,513 | 240.3 kb | Distal (>10kb) Multiome | 224 | |
| chr8:138,081,105–138,081,940 | 2.2 kb | Proximal (<10kb) Multiome | 137 | |
| chr8:138,082,125–138,082,797 | 772 bp | At TSS | 7 | |
| chr8:138,083,089–138,083,259 | 310 bp | At TSS | 5 | |
| chr8:138,189,427–138,191,275 | 106.3 kb | Distal (>10kb) Multiome | 103 | |
| chr8:138,259,894–138,260,802 | 176.6 kb | Distal (>10kb) Multiome | 295 |
Genomic view of the ENSG00000253288 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.