Transcription factors with Perturb-seq knockdown data for ENSG00000253284. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000253284 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000253284, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:18,752,383–18,754,593 | 394.2 kb | Distal (>10kb) Multiome HiCAR | 426 | |
| chr12:18,895,789–18,896,600 | 250.9 kb | Distal (>10kb) Multiome | 128 | |
| chr12:19,129,141–19,131,343 | 17.4 kb | Distal (>10kb) Multiome | 714 | |
| chr12:19,139,678–19,140,097 | 7.0 kb | Proximal (<10kb) | 31 | |
| chr12:19,439,042–19,440,856 | 292.4 kb | Distal (>10kb) Multiome | 887 |
Genomic view of the ENSG00000253284 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.