Transcription factors with Perturb-seq knockdown data for ENSG00000250994. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000250994 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000250994, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:134,140,528–134,140,995 | 295.9 kb | Distal (>10kb) Multiome | 342 | |
| chr5:134,176,142–134,177,562 | 259.7 kb | Distal (>10kb) Multiome | 952 | |
| chr5:134,184,086–134,184,650 | 252.3 kb | Distal (>10kb) Multiome | 289 | |
| chr5:134,225,248–134,227,248 | 210.4 kb | Distal (>10kb) Multiome | 1043 | |
| chr5:134,366,722–134,367,362 | 69.5 kb | Distal (>10kb) Multiome | 682 | |
| chr5:134,370,722–134,372,303 | 65.4 kb | Distal (>10kb) Multiome | 1080 | |
| chr5:134,411,465–134,412,433 | 24.7 kb | Distal (>10kb) Multiome | 989 | |
| chr5:134,427,679–134,428,029 | 8.7 kb | Proximal (<10kb) | 58 | |
| chr5:134,465,626–134,467,213 | 29.2 kb | Distal (>10kb) Multiome | 926 | |
| chr5:134,506,114–134,506,990 | 69.7 kb | Distal (>10kb) Multiome HiCAR | 644 | |
| chr5:134,511,761–134,512,800 | 75.6 kb | Distal (>10kb) Multiome HiCAR | 505 | |
| chr5:134,523,964–134,528,361 | 90.8 kb | Distal (>10kb) Multiome HiCAR | 1077 | |
| chr5:134,539,671–134,540,206 | 103.2 kb | Distal (>10kb) Multiome HiCAR | 144 | |
| chr5:134,586,828–134,587,543 | 150.5 kb | Distal (>10kb) Multiome | 407 | |
| chr5:134,632,348–134,633,007 | 196.1 kb | Distal (>10kb) Multiome | 1019 | |
| chr5:134,648,377–134,649,305 | 212.1 kb | Distal (>10kb) Multiome | 995 |
Genomic view of the ENSG00000250994 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.