Transcription factors with Perturb-seq knockdown data for ENSG00000250519. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000250519 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000250519, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:93,849,777–93,850,638 | 387.9 kb | Distal (>10kb) Multiome HiCAR | 277 | |
| chr11:94,128,241–94,129,803 | 109.3 kb | Distal (>10kb) Multiome | 920 | |
| chr11:94,351,024–94,351,644 | 113.1 kb | Distal (>10kb) Multiome | 45 | |
| chr11:94,400,876–94,402,024 | 163.3 kb | Distal (>10kb) Multiome | 221 | |
| chr11:94,493,226–94,494,559 | 255.7 kb | Distal (>10kb) Multiome | 772 | |
| chr11:94,512,016–94,512,839 | 274.3 kb | Distal (>10kb) Multiome | 343 |
Genomic view of the ENSG00000250519 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.