Transcription factors with Perturb-seq knockdown data for ENSG00000249738. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000249738 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000249738, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:159,099,838–159,101,146 | 210.3 kb | Distal (>10kb) Multiome | 500 | |
| chr5:159,208,643–159,210,083 | 101.1 kb | Distal (>10kb) Multiome | 898 | |
| chr5:159,262,736–159,263,791 | 47.5 kb | Distal (>10kb) Multiome | 849 | |
| chr5:159,310,052–159,310,886 | at TSS | At TSS | 194 | |
| chr5:159,316,870–159,317,087 | 6.1 kb | Proximal (<10kb) | 124 | |
| chr5:159,331,221–159,332,012 | 20.9 kb | Distal (>10kb) Multiome | 487 | |
| chr5:159,416,519–159,417,760 | 106.6 kb | Distal (>10kb) Multiome HiCAR | 142 | |
| chr5:159,442,094–159,442,787 | 131.8 kb | Distal (>10kb) Multiome | 60 | |
| chr5:159,510,131–159,510,890 | 199.7 kb | Distal (>10kb) Multiome | 235 | |
| chr5:159,571,561–159,572,337 | 261.3 kb | Distal (>10kb) Multiome | 225 | |
| chr5:159,620,820–159,621,788 | 310.6 kb | Distal (>10kb) Multiome | 199 | |
| chr5:159,971,757–159,973,420 | 661.4 kb | Distal (>10kb) Multiome HiCAR | 189 | |
| chr5:159,986,837–159,987,682 | 676.7 kb | Distal (>10kb) Multiome HiCAR | 416 | |
| chr5:160,008,719–160,009,383 | 698.3 kb | Distal (>10kb) Multiome HiCAR | 737 | |
| chr5:160,399,366–160,400,211 | 1089.1 kb | Distal (>10kb) Multiome HiCAR | 808 |
Genomic view of the ENSG00000249738 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.