Transcription factors with Perturb-seq knockdown data for ENSG00000249456. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000249456 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000249456, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:124,743,297–124,744,966 | 172.8 kb | Distal (>10kb) Multiome | 546 | |
| chr10:124,791,269–124,792,470 | 125.3 kb | Distal (>10kb) Multiome | 976 | |
| chr10:124,800,254–124,802,352 | 115.3 kb | Distal (>10kb) Multiome | 821 | |
| chr10:124,916,459–124,917,959 | 307 bp | At TSS Multiome | 843 | |
| chr10:125,048,088–125,048,633 | 131.2 kb | Distal (>10kb) Multiome | 344 | |
| chr10:125,151,246–125,153,639 | 234.9 kb | Distal (>10kb) Multiome | 450 | |
| chr10:125,159,798–125,162,908 | 244.1 kb | Distal (>10kb) Multiome | 658 |
Genomic view of the ENSG00000249456 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.