Transcription factors with Perturb-seq knockdown data for ENSG00000249207. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000249207 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000249207, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:39,044,055–39,045,485 | 137.6 kb | Distal (>10kb) Multiome | 636 | |
| chr4:39,135,136–39,135,640 | 46.8 kb | Distal (>10kb) Multiome | 399 | |
| chr4:39,181,955–39,183,542 | 108 bp | At TSS Multiome | 644 | |
| chr4:39,365,894–39,366,933 | 184.1 kb | Distal (>10kb) Multiome | 1045 | |
| chr4:39,446,525–39,447,613 | 264.8 kb | Distal (>10kb) Multiome | 443 | |
| chr4:39,458,264–39,459,604 | 276.7 kb | Distal (>10kb) Multiome | 1000 |
Genomic view of the ENSG00000249207 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.