Transcription factors with Perturb-seq knockdown data for ENSG00000248367. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000248367 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000248367, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:180,007,647–180,008,169 | 284.3 kb | Distal (>10kb) Multiome | 251 | |
| chr5:180,059,605–180,060,144 | 232.4 kb | Distal (>10kb) Multiome | 18 | |
| chr5:180,069,680–180,070,372 | 222.2 kb | Distal (>10kb) Multiome | 240 | |
| chr5:180,071,104–180,072,473 | 220.2 kb | Distal (>10kb) Multiome | 1084 | |
| chr5:180,090,117–180,091,054 | 201.7 kb | Distal (>10kb) Multiome | 575 | |
| chr5:180,208,671–180,209,518 | 83.0 kb | Distal (>10kb) Multiome | 385 | |
| chr5:180,289,519–180,289,755 | 2.4 kb | Proximal (<10kb) | 109 | |
| chr5:180,291,390–180,292,854 | 94 bp | At TSS Multiome | 694 | |
| chr5:180,292,972–180,293,953 | 1.5 kb | Proximal (<10kb) Multiome | 556 | |
| chr5:180,352,255–180,354,009 | 61.3 kb | Distal (>10kb) Multiome | 450 | |
| chr5:180,493,929–180,495,203 | 202.2 kb | Distal (>10kb) Multiome | 803 |
Genomic view of the ENSG00000248367 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.