Transcription factors with Perturb-seq knockdown data for ENSG00000243944. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000243944 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000243944, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:149,752,004–149,753,499 | 286.5 kb | Distal (>10kb) Multiome | 991 | |
| chr3:149,812,342–149,813,957 | 226.1 kb | Distal (>10kb) Multiome | 918 | |
| chr3:149,969,831–149,971,970 | 68.0 kb | Distal (>10kb) Multiome | 920 | |
| chr3:150,035,407–150,035,667 | 3.5 kb | Proximal (<10kb) | 32 | |
| chr3:150,097,150–150,098,142 | 58.4 kb | Distal (>10kb) Multiome | 220 | |
| chr3:150,130,019–150,131,345 | 91.3 kb | Distal (>10kb) Multiome | 166 | |
| chr3:150,165,261–150,165,994 | 126.5 kb | Distal (>10kb) Multiome | 106 | |
| chr3:150,215,844–150,216,844 | 177.1 kb | Distal (>10kb) Multiome | 265 |
Genomic view of the ENSG00000243944 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.