Transcription factors with Perturb-seq knockdown data for ENSG00000240086. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000240086 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000240086, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:134,794,772–134,796,898 | 644.7 kb | Distal (>10kb) Multiome HiCAR | 524 | |
| chr3:135,166,588–135,167,889 | 272.6 kb | Distal (>10kb) Multiome | 93 | |
| chr3:135,439,254–135,439,879 | at TSS | At TSS | 60 | |
| chr3:135,503,661–135,504,167 | 64.1 kb | Distal (>10kb) Multiome | 178 | |
| chr3:135,690,450–135,691,432 | 251.0 kb | Distal (>10kb) Multiome | 63 |
Genomic view of the ENSG00000240086 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.