Transcription factors with Perturb-seq knockdown data for ENSG00000237316. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000237316 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000237316, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:33,919,375–33,922,666 | 803.8 kb | Distal (>10kb) Multiome HiCAR | 656 | |
| chr22:34,834,409–34,834,881 | 109.9 kb | Distal (>10kb) Multiome | 21 | |
| chr22:34,836,688–34,837,824 | 112.4 kb | Distal (>10kb) Multiome | 39 |
Genomic view of the ENSG00000237316 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.