Transcription factors with Perturb-seq knockdown data for ENSG00000236643. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000236643 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000236643, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,760,800–124,761,064 | 9.1 kb | Proximal (<10kb) | 67 | |
| chr9:124,769,647–124,772,472 | at TSS | At TSS | 1006 | |
| chr9:124,774,457–124,774,680 | 4.3 kb | Proximal (<10kb) | 288 | |
| chr9:124,776,976–124,778,058 | 6.9 kb | Proximal (<10kb) | 349 | |
| chr9:124,779,329–124,780,041 | 9.2 kb | Proximal (<10kb) | 260 |
Genomic view of the ENSG00000236643 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.