Transcription factors with Perturb-seq knockdown data for ENSG00000236255. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000236255 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000236255, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:117,814,354–117,815,236 | 21.6 kb | Distal (>10kb) Multiome | 987 | |
| chr2:117,835,820–117,836,917 | 34 bp | At TSS Multiome | 337 | |
| chr2:117,849,927–117,850,957 | 14.3 kb | Distal (>10kb) Multiome | 288 | |
| chr2:117,851,735–117,852,372 | 15.9 kb | Distal (>10kb) Multiome | 96 | |
| chr2:117,853,013–117,853,974 | 17.3 kb | Distal (>10kb) Multiome | 109 | |
| chr2:117,854,448–117,855,028 | 18.7 kb | Distal (>10kb) Multiome | 71 | |
| chr2:118,013,165–118,014,769 | 177.8 kb | Distal (>10kb) Multiome | 833 | |
| chr2:118,087,899–118,089,495 | 252.1 kb | Distal (>10kb) Multiome | 907 | |
| chr2:118,855,419–118,856,205 | 1019.5 kb | Distal (>10kb) Multiome HiCAR | 527 |
Genomic view of the ENSG00000236255 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.