Transcription factors with Perturb-seq knockdown data for ENSG00000235494. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235494 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235494, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,013,175–97,013,888 | 209.0 kb | Distal (>10kb) Multiome | 273 | |
| chr9:97,038,375–97,039,810 | 183.4 kb | Distal (>10kb) Multiome | 639 | |
| chr9:97,051,679–97,052,459 | 170.6 kb | Distal (>10kb) Multiome | 224 | |
| chr9:97,214,476–97,215,067 | 7.9 kb | Proximal (<10kb) Multiome | 48 | |
| chr9:97,216,229–97,216,695 | 5.9 kb | Proximal (<10kb) | 48 | |
| chr9:97,220,933–97,222,786 | 917 bp | At TSS Multiome | 231 | |
| chr9:97,231,971–97,232,981 | 9.9 kb | Proximal (<10kb) Multiome | 260 | |
| chr9:97,238,002–97,238,892 | 15.9 kb | Distal (>10kb) Multiome | 684 | |
| chr9:97,306,799–97,308,104 | 84.7 kb | Distal (>10kb) Multiome | 182 | |
| chr9:97,386,832–97,387,759 | 164.6 kb | Distal (>10kb) Multiome | 555 | |
| chr9:97,411,603–97,412,682 | 189.4 kb | Distal (>10kb) Multiome | 864 | |
| chr9:97,436,823–97,437,760 | 214.8 kb | Distal (>10kb) Multiome | 98 | |
| chr9:97,501,163–97,503,374 | 278.9 kb | Distal (>10kb) Multiome | 581 |
Genomic view of the ENSG00000235494 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.