Transcription factors with Perturb-seq knockdown data for ENSG00000234595. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000234595 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000234595, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:181,677,659–181,678,624 | 4.5 kb | Proximal (<10kb) | 585 | |
| chr2:181,679,567–181,680,020 | 3.1 kb | Proximal (<10kb) | 62 | |
| chr2:181,680,198–181,681,989 | 1.1 kb | Proximal (<10kb) | 316 | |
| chr2:181,682,538–181,684,472 | at TSS | At TSS | 355 | |
| chr2:181,685,109–181,685,573 | 2.0 kb | Proximal (<10kb) | 162 |
Genomic view of the ENSG00000234595 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.