Transcription factors with Perturb-seq knockdown data for ENSG00000232063. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000232063 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000232063, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:94,165,559–94,167,324 | 165.6 kb | Distal (>10kb) Multiome | 1085 | |
| chr9:94,250,394–94,250,997 | 81.6 kb | Distal (>10kb) Multiome | 81 | |
| chr9:94,259,139–94,259,781 | 73.1 kb | Distal (>10kb) Multiome | 663 | |
| chr9:94,338,800–94,338,989 | 6.3 kb | Proximal (<10kb) | 7 | |
| chr9:94,374,230–94,375,026 | 42.1 kb | Distal (>10kb) Multiome | 332 | |
| chr9:94,552,994–94,555,388 | 222.4 kb | Distal (>10kb) Multiome | 631 | |
| chr9:94,608,138–94,608,779 | 275.9 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the ENSG00000232063 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.