Transcription factors with Perturb-seq knockdown data for ENSG00000231781. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000231781 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000231781, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:81,078,268–81,079,188 | 926.9 kb | Distal (>10kb) Multiome HiCAR | 85 | |
| chr2:82,001,959–82,003,011 | 3.2 kb | Proximal (<10kb) Multiome | 130 | |
| chr2:82,004,304–82,004,818 | 881 bp | At TSS | 12 | |
| chr2:82,005,238–82,006,256 | 192 bp | At TSS Multiome | 95 | |
| chr2:82,013,551–82,014,284 | 8.2 kb | Proximal (<10kb) Multiome | 178 | |
| chr2:82,030,758–82,031,660 | 25.3 kb | Distal (>10kb) Multiome | 91 | |
| chr2:82,260,381–82,261,825 | 255.4 kb | Distal (>10kb) Multiome HiCAR | 150 |
Genomic view of the ENSG00000231781 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.