Transcription factors with Perturb-seq knockdown data for ENSG00000231563. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000231563 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000231563, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:228,108,924–228,110,105 | 297.8 kb | Distal (>10kb) Multiome | 958 | |
| chr1:228,130,684–228,131,457 | 276.1 kb | Distal (>10kb) Multiome | 488 | |
| chr1:228,139,579–228,140,870 | 267.1 kb | Distal (>10kb) Multiome | 931 | |
| chr1:228,164,898–228,166,840 | 241.4 kb | Distal (>10kb) Multiome | 1011 | |
| chr1:228,212,247–228,214,390 | 193.5 kb | Distal (>10kb) Multiome | 604 | |
| chr1:228,275,524–228,276,595 | 131.1 kb | Distal (>10kb) Multiome | 428 | |
| chr1:228,378,133–228,379,597 | 28.5 kb | Distal (>10kb) Multiome | 515 | |
| chr1:228,406,106–228,407,568 | 199 bp | At TSS Multiome | 753 | |
| chr1:228,416,050–228,416,929 | 9.3 kb | Proximal (<10kb) Multiome | 279 | |
| chr1:228,457,070–228,458,723 | 50.7 kb | Distal (>10kb) Multiome HiCAR | 800 | |
| chr1:228,458,870–228,459,670 | 52.2 kb | Distal (>10kb) Multiome HiCAR | 503 | |
| chr1:228,464,228–228,465,055 | 57.6 kb | Distal (>10kb) Multiome | 204 | |
| chr1:228,486,589–228,487,963 | 80.1 kb | Distal (>10kb) Multiome | 1041 | |
| chr1:228,647,259–228,648,459 | 240.8 kb | Distal (>10kb) Multiome | 684 |
Genomic view of the ENSG00000231563 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.