Transcription factors with Perturb-seq knockdown data for ENSG00000231424. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000231424 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000231424, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:171,219,608–171,221,098 | 31.1 kb | Distal (>10kb) Multiome | 330 | |
| chr1:171,245,552–171,245,756 | 6.0 kb | Proximal (<10kb) | 138 | |
| chr1:171,251,029–171,251,978 | at TSS | At TSS | 237 | |
| chr1:171,258,839–171,259,220 | 7.0 kb | Proximal (<10kb) | 17 | |
| chr1:171,313,680–171,314,256 | 62.3 kb | Distal (>10kb) Multiome HiCAR | 512 | |
| chr1:171,431,769–171,432,338 | 180.4 kb | Distal (>10kb) Multiome | 65 | |
| chr1:171,484,908–171,486,487 | 233.7 kb | Distal (>10kb) Multiome | 978 |
Genomic view of the ENSG00000231424 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.