Transcription factors with Perturb-seq knockdown data for ENSG00000230975. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000230975 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000230975, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:80,868,144–80,869,407 | 782 bp | At TSS | 27 | |
| chr2:80,870,153–80,870,949 | at TSS | At TSS | 76 | |
| chr2:80,874,058–80,874,687 | 3.9 kb | Proximal (<10kb) | 105 | |
| chr2:80,878,359–80,878,569 | 8.2 kb | Proximal (<10kb) | 1 |
Genomic view of the ENSG00000230975 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.