Transcription factors with Perturb-seq knockdown data for ENSG00000230773. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000230773 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000230773, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:48,047,158–48,047,658 | 266.8 kb | Distal (>10kb) Multiome | 156 | |
| chr2:48,106,181–48,107,250 | 207.5 kb | Distal (>10kb) Multiome | 634 | |
| chr2:48,111,016–48,112,408 | 202.6 kb | Distal (>10kb) Multiome HiCAR | 971 | |
| chr2:48,240,781–48,241,318 | 73.1 kb | Distal (>10kb) Multiome | 17 | |
| chr2:48,283,598–48,284,166 | 30.4 kb | Distal (>10kb) Multiome | 174 | |
| chr2:48,313,984–48,316,177 | 254 bp | At TSS Multiome | 1153 | |
| chr2:48,440,147–48,441,725 | 126.5 kb | Distal (>10kb) Multiome | 921 | |
| chr2:48,529,168–48,530,907 | 216.0 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the ENSG00000230773 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.