Transcription factors with Perturb-seq knockdown data for ENSG00000230333. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000230333 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000230333, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:10,939,396–10,941,296 | 253.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr7:10,972,785–10,974,913 | 219.6 kb | Distal (>10kb) Multiome | 896 | |
| chr7:11,185,053–11,185,848 | 7.5 kb | Proximal (<10kb) | 153 | |
| chr7:11,188,747–11,189,209 | 4.2 kb | Proximal (<10kb) | 40 | |
| chr7:11,191,025–11,191,438 | 1.9 kb | Proximal (<10kb) | 26 | |
| chr7:11,191,568–11,192,176 | 1.2 kb | Proximal (<10kb) | 114 | |
| chr7:11,193,012–11,194,168 | at TSS | At TSS | 384 | |
| chr7:11,197,333–11,197,696 | 4.0 kb | Proximal (<10kb) | 3 | |
| chr7:11,234,831–11,236,097 | 42.3 kb | Distal (>10kb) Multiome | 97 | |
| chr7:11,491,727–11,492,441 | 298.6 kb | Distal (>10kb) Multiome | 117 |
Genomic view of the ENSG00000230333 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.