Transcription factors with Perturb-seq knockdown data for ENSG00000229618. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000229618 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000229618, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:12,570,159–12,571,611 | 231.3 kb | Distal (>10kb) Multiome | 430 | |
| chr7:12,686,188–12,688,064 | 114.7 kb | Distal (>10kb) Multiome | 1066 | |
| chr7:12,715,491–12,716,600 | 86.3 kb | Distal (>10kb) Multiome | 633 | |
| chr7:12,796,589–12,797,071 | 5.2 kb | Proximal (<10kb) | 72 | |
| chr7:12,802,077–12,802,488 | at TSS | At TSS | 158 | |
| chr7:13,017,062–13,018,256 | 215.3 kb | Distal (>10kb) Multiome | 585 |
Genomic view of the ENSG00000229618 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.