Transcription factors with Perturb-seq knockdown data for ENSG00000229337. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000229337 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000229337, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:176,122,221–176,123,570 | 1089.7 kb | Distal (>10kb) Multiome HiCAR | 242 | |
| chr2:177,204,472–177,204,729 | 7.9 kb | Proximal (<10kb) | 34 | |
| chr2:177,211,967–177,213,482 | 7 bp | At TSS Multiome | 1144 | |
| chr2:177,263,465–177,265,584 | 52.3 kb | Distal (>10kb) Multiome | 1275 | |
| chr2:177,392,346–177,393,257 | 180.1 kb | Distal (>10kb) Multiome | 1012 |
Genomic view of the ENSG00000229337 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.