TFs regulating ENSG00000229191 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000229191. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000229191 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000229191

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000229191, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:200,738,299–200,740,095	284.9 kb	Distal (>10kb) Multiome	831
chr1:200,890,766–200,892,246	132.5 kb	Distal (>10kb) Multiome	761
chr1:200,915,808–200,916,700	107.6 kb	Distal (>10kb) Multiome	219
chr1:201,014,162–201,014,786	9.4 kb	Proximal (<10kb) Multiome	160
chr1:201,015,562–201,016,315	7.6 kb	Proximal (<10kb)	232
chr1:201,020,041–201,020,958	3.0 kb	Proximal (<10kb)	289
chr1:201,021,071–201,021,621	2.6 kb	Proximal (<10kb) Multiome	164
chr1:201,022,936–201,024,467	244 bp	At TSS Multiome	436
chr1:201,113,946–201,115,250	90.4 kb	Distal (>10kb) Multiome HiCAR	594
chr1:201,153,600–201,155,169	130.5 kb	Distal (>10kb) Multiome	713
chr1:201,170,516–201,172,002	147.0 kb	Distal (>10kb) Multiome	988
chr1:201,259,443–201,260,371	235.9 kb	Distal (>10kb) Multiome	253
chr1:201,283,211–201,283,740	259.6 kb	Distal (>10kb) Multiome	190

Genome Browser

Genomic view of the ENSG00000229191 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.