Transcription factors with Perturb-seq knockdown data for ENSG00000228739. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000228739 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000228739, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:5,831,978–5,833,476 | 214.4 kb | Distal (>10kb) Multiome | 896 | |
| chr9:5,885,989–5,886,773 | 161.0 kb | Distal (>10kb) Multiome HiCAR | 419 | |
| chr9:6,006,744–6,008,942 | 39.0 kb | Distal (>10kb) Multiome | 899 | |
| chr9:6,015,337–6,016,019 | 31.7 kb | Distal (>10kb) Multiome | 705 | |
| chr9:6,021,445–6,021,997 | 25.7 kb | Distal (>10kb) Multiome | 90 | |
| chr9:6,048,940–6,049,163 | 1.6 kb | Proximal (<10kb) | 5 | |
| chr9:6,049,327–6,050,383 | 2.7 kb | Proximal (<10kb) Multiome | 170 | |
| chr9:6,054,400–6,054,808 | 7.0 kb | Proximal (<10kb) | 175 | |
| chr9:6,055,294–6,055,504 | 7.9 kb | Proximal (<10kb) | 144 | |
| chr9:6,080,023–6,081,094 | 33.1 kb | Distal (>10kb) Multiome | 455 |
Genomic view of the ENSG00000228739 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.