Transcription factors with Perturb-seq knockdown data for ENSG00000228566. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000228566 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000228566, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:63,629,052–63,631,108 | 242.9 kb | Distal (>10kb) Multiome | 968 | |
| chr10:63,713,131–63,714,105 | 159.1 kb | Distal (>10kb) Multiome | 440 | |
| chr10:63,865,289–63,865,623 | 6.9 kb | Proximal (<10kb) | 69 | |
| chr10:63,865,963–63,867,299 | 6.0 kb | Proximal (<10kb) Multiome | 269 | |
| chr10:63,872,009–63,872,619 | at TSS | At TSS | 147 | |
| chr10:64,041,025–64,042,264 | 168.9 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the ENSG00000228566 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.