Transcription factors with Perturb-seq knockdown data for ENSG00000227712. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227712 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227712, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:119,139,495–119,141,414 | 186.7 kb | Distal (>10kb) Multiome | 945 | |
| chr1:119,322,036–119,323,428 | 3.8 kb | Proximal (<10kb) | 59 | |
| chr1:119,326,262–119,326,755 | 460 bp | At TSS | 67 | |
| chr1:119,326,868–119,328,207 | 491 bp | At TSS Multiome | 644 | |
| chr1:119,331,704–119,332,439 | 4.5 kb | Proximal (<10kb) | 136 | |
| chr1:119,340,746–119,341,560 | 13.9 kb | Distal (>10kb) Multiome | 375 | |
| chr1:119,611,469–119,612,104 | 284.6 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the ENSG00000227712 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.