Transcription factors with Perturb-seq knockdown data for ENSG00000227355. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227355 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227355, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:121,074,349–121,075,511 | 295.4 kb | Distal (>10kb) Multiome | 1041 | |
| chr9:121,121,551–121,122,082 | 248.7 kb | Distal (>10kb) Multiome | 539 | |
| chr9:121,201,011–121,202,492 | 168.5 kb | Distal (>10kb) Multiome | 850 | |
| chr9:121,221,026–121,221,471 | 149.1 kb | Distal (>10kb) Multiome | 78 | |
| chr9:121,267,686–121,269,264 | 102.4 kb | Distal (>10kb) Multiome | 550 | |
| chr9:121,286,406–121,287,700 | 83.1 kb | Distal (>10kb) Multiome | 735 | |
| chr9:121,299,542–121,300,058 | 70.7 kb | Distal (>10kb) Multiome | 428 | |
| chr9:121,369,661–121,370,788 | 102 bp | At TSS Multiome | 849 | |
| chr9:121,499,468–121,500,318 | 129.5 kb | Distal (>10kb) Multiome | 361 | |
| chr9:121,545,736–121,546,521 | 175.7 kb | Distal (>10kb) Multiome | 559 | |
| chr9:121,550,534–121,551,203 | 180.3 kb | Distal (>10kb) Multiome | 479 | |
| chr9:121,573,659–121,574,394 | 203.5 kb | Distal (>10kb) Multiome | 41 | |
| chr9:121,597,811–121,598,880 | 227.8 kb | Distal (>10kb) Multiome | 345 | |
| chr9:121,598,949–121,600,205 | 229.1 kb | Distal (>10kb) Multiome | 448 | |
| chr9:121,650,102–121,650,775 | 279.9 kb | Distal (>10kb) Multiome | 435 | |
| chr9:121,651,183–121,652,085 | 281.1 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the ENSG00000227355 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.