Transcription factors with Perturb-seq knockdown data for ENSG00000226266. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226266 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226266, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:159,614,971–159,616,729 | 96.9 kb | Distal (>10kb) Multiome | 950 | |
| chr2:159,711,895–159,713,118 | 101 bp | At TSS Multiome | 1191 | |
| chr2:159,797,654–159,798,386 | 85.7 kb | Distal (>10kb) Multiome | 794 | |
| chr2:159,903,833–159,905,297 | 192.3 kb | Distal (>10kb) Multiome | 416 | |
| chr2:159,921,615–159,922,304 | 209.5 kb | Distal (>10kb) Multiome | 433 |
Genomic view of the ENSG00000226266 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.