Transcription factors with Perturb-seq knockdown data for ENSG00000224076. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000224076 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000224076, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:161,413,932–161,417,535 | 6.0 kb | Proximal (<10kb) | 691 | |
| chr2:161,417,732–161,419,279 | 4.3 kb | Proximal (<10kb) | 374 | |
| chr2:161,421,806–161,422,147 | 1.4 kb | Proximal (<10kb) | 12 | |
| chr2:161,422,463–161,424,682 | at TSS | At TSS | 296 | |
| chr2:161,426,467–161,428,505 | 2.9 kb | Proximal (<10kb) | 275 |
Genomic view of the ENSG00000224076 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.