Transcription factors with Perturb-seq knockdown data for ENSG00000223725. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000223725 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000223725, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:207,334,461–207,335,111 | 195.0 kb | Distal (>10kb) Multiome | 312 | |
| chr2:207,408,155–207,408,852 | 121.3 kb | Distal (>10kb) Multiome | 224 | |
| chr2:207,473,001–207,473,846 | 56.3 kb | Distal (>10kb) Multiome | 203 | |
| chr2:207,528,862–207,530,966 | 78 bp | At TSS Multiome | 969 | |
| chr2:207,624,610–207,626,664 | 96.2 kb | Distal (>10kb) Multiome | 1079 | |
| chr2:207,681,149–207,682,035 | 151.8 kb | Distal (>10kb) Multiome | 73 | |
| chr2:207,710,626–207,712,680 | 181.7 kb | Distal (>10kb) Multiome | 950 | |
| chr2:207,765,723–207,766,484 | 236.2 kb | Distal (>10kb) Multiome | 343 | |
| chr2:207,766,763–207,771,365 | 240.2 kb | Distal (>10kb) Multiome | 1084 | |
| chr2:207,796,609–207,797,752 | 267.3 kb | Distal (>10kb) Multiome | 545 | |
| chr2:207,800,773–207,801,891 | 271.6 kb | Distal (>10kb) Multiome | 374 | |
| chr2:207,810,355–207,811,806 | 281.4 kb | Distal (>10kb) Multiome | 482 |
Genomic view of the ENSG00000223725 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.