Transcription factors with Perturb-seq knockdown data for ENSG00000197462. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000197462 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000197462, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:125,637,770–125,638,484 | 279.8 kb | Distal (>10kb) Multiome | 116 | |
| chr7:125,915,121–125,915,877 | 2.3 kb | Proximal (<10kb) Multiome | 140 | |
| chr7:125,919,115–125,919,434 | 1.2 kb | Proximal (<10kb) | 3 | |
| chr7:125,921,820–125,922,347 | 4.0 kb | Proximal (<10kb) | 30 | |
| chr7:125,922,653–125,924,380 | 4.8 kb | Proximal (<10kb) | 177 | |
| chr7:125,927,546–125,927,895 | 9.7 kb | Proximal (<10kb) | 97 | |
| chr7:126,185,800–126,186,676 | 268.4 kb | Distal (>10kb) Multiome | 117 |
Genomic view of the ENSG00000197462 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.