The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]
Transcription factors with Perturb-seq knockdown data for ENPEP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENPEP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENPEP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:110,195,911–110,198,252 | 279.5 kb | Distal (>10kb) Multiome | 806 | |
| chr4:110,198,361–110,199,448 | 277.4 kb | Distal (>10kb) Multiome | 817 | |
| chr4:110,411,354–110,412,301 | 64.3 kb | Distal (>10kb) Multiome | 372 | |
| chr4:110,472,344–110,473,712 | 2.4 kb | Proximal (<10kb) | 307 | |
| chr4:110,613,796–110,614,882 | 138.2 kb | Distal (>10kb) Multiome | 225 | |
| chr4:110,615,006–110,616,645 | 139.7 kb | Distal (>10kb) Multiome | 226 | |
| chr4:110,617,892–110,620,263 | 143.5 kb | Distal (>10kb) Multiome | 335 | |
| chr4:110,620,638–110,627,477 | 147.0 kb | Distal (>10kb) Multiome | 562 | |
| chr4:110,630,610–110,633,369 | 154.7 kb | Distal (>10kb) Multiome | 525 |
Genomic view of the ENPEP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.