Transcription factors with Perturb-seq knockdown data for EMSLR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EMSLR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EMSLR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:101,085,076–101,085,958 | 222.8 kb | Distal (>10kb) Multiome | 732 | |
| chr7:101,153,861–101,155,183 | 153.8 kb | Distal (>10kb) Multiome | 670 | |
| chr7:101,162,599–101,164,796 | 145.2 kb | Distal (>10kb) Multiome | 654 | |
| chr7:101,165,195–101,166,546 | 142.6 kb | Distal (>10kb) Multiome | 980 | |
| chr7:101,173,985–101,174,835 | 134.1 kb | Distal (>10kb) Multiome | 323 | |
| chr7:101,216,957–101,218,626 | 90.5 kb | Distal (>10kb) Multiome | 918 | |
| chr7:101,232,007–101,233,160 | 75.8 kb | Distal (>10kb) Multiome | 304 | |
| chr7:101,244,041–101,245,521 | 63.3 kb | Distal (>10kb) Multiome | 989 | |
| chr7:101,251,898–101,252,786 | 55.9 kb | Distal (>10kb) Multiome | 751 | |
| chr7:101,282,845–101,283,297 | 25.2 kb | Distal (>10kb) Multiome | 300 | |
| chr7:101,294,017–101,295,035 | 14.0 kb | Distal (>10kb) Multiome | 188 | |
| chr7:101,299,826–101,300,551 | 8.2 kb | Proximal (<10kb) Multiome | 147 | |
| chr7:101,302,606–101,303,724 | 5.4 kb | Proximal (<10kb) Multiome | 167 | |
| chr7:101,308,000–101,309,265 | 40 bp | At TSS Multiome | 357 | |
| chr7:101,321,440–101,322,377 | 13.5 kb | Distal (>10kb) Multiome | 537 | |
| chr7:101,362,703–101,363,475 | 54.6 kb | Distal (>10kb) Multiome | 258 | |
| chr7:101,363,545–101,364,217 | 55.8 kb | Distal (>10kb) Multiome | 584 | |
| chr7:101,411,116–101,411,868 | 103.1 kb | Distal (>10kb) Multiome | 307 | |
| chr7:101,420,273–101,420,839 | 112.4 kb | Distal (>10kb) Multiome | 54 | |
| chr7:101,602,457–101,603,098 | 294.4 kb | Distal (>10kb) Multiome | 367 |
Genomic view of the EMSLR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.