This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for EML4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EML4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EML4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:41,937,467–41,937,918 | 231.8 kb | Distal (>10kb) Multiome | 159 | |
| chr2:41,947,579–41,949,439 | 221.5 kb | Distal (>10kb) Multiome | 291 | |
| chr2:41,992,220–41,993,306 | 176.5 kb | Distal (>10kb) Multiome | 188 | |
| chr2:42,036,200–42,036,946 | 132.7 kb | Distal (>10kb) Multiome | 103 | |
| chr2:42,045,917–42,049,213 | 121.4 kb | Distal (>10kb) Multiome | 846 | |
| chr2:42,063,372–42,064,229 | 105.4 kb | Distal (>10kb) Multiome | 198 | |
| chr2:42,100,746–42,103,242 | 66.6 kb | Distal (>10kb) Multiome | 703 | |
| chr2:42,132,557–42,133,741 | 36.1 kb | Distal (>10kb) Multiome | 986 | |
| chr2:42,141,041–42,142,131 | 27.7 kb | Distal (>10kb) Multiome | 699 | |
| chr2:42,168,640–42,170,239 | 50 bp | At TSS Multiome | 913 | |
| chr2:42,183,806–42,184,606 | 14.8 kb | Distal (>10kb) Multiome | 233 | |
| chr2:42,196,297–42,197,267 | 27.4 kb | Distal (>10kb) Multiome | 571 | |
| chr2:42,360,768–42,362,053 | 192.2 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the EML4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.