Contributes to membrane insertase activity. Involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane and omegasome membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EMC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EMC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EMC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:3,529,956–3,530,848 | 138.4 kb | Distal (>10kb) Multiome | 320 | |
| chr17:3,535,341–3,536,205 | 133.2 kb | Distal (>10kb) Multiome | 356 | |
| chr17:3,546,350–3,546,812 | 122.2 kb | Distal (>10kb) Multiome | 106 | |
| chr17:3,635,650–3,637,225 | 32.4 kb | Distal (>10kb) Multiome | 866 | |
| chr17:3,667,393–3,669,475 | 178 bp | At TSS Multiome | 949 | |
| chr17:3,723,432–3,724,429 | 55.0 kb | Distal (>10kb) Multiome | 865 | |
| chr17:3,754,197–3,755,835 | 86.1 kb | Distal (>10kb) Multiome | 396 | |
| chr17:3,845,518–3,846,549 | 177.5 kb | Distal (>10kb) Multiome | 917 | |
| chr17:3,891,925–3,893,745 | 224.5 kb | Distal (>10kb) Multiome | 716 | |
| chr17:3,944,497–3,945,384 | 276.1 kb | Distal (>10kb) Multiome | 277 | |
| chr17:3,964,969–3,965,418 | 296.4 kb | Distal (>10kb) Multiome | 333 |
Genomic view of the EMC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.