Predicted to be involved in positive regulation of cell migration. Predicted to act upstream of or within several processes, including autophagosome maturation; gene expression; and homeostasis of number of retina cells. Located in cytosol and nucleus. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ELP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:47,281,636–47,283,234 | 230.6 kb | Distal (>10kb) Multiome | 941 | |
| chr3:47,380,120–47,381,966 | 132.4 kb | Distal (>10kb) Multiome | 1058 | |
| chr3:47,475,384–47,476,386 | 37.4 kb | Distal (>10kb) Multiome | 967 | |
| chr3:47,512,910–47,514,044 | 209 bp | At TSS Multiome | 892 | |
| chr3:47,522,175–47,522,702 | 9.0 kb | Proximal (<10kb) Multiome | 591 | |
| chr3:47,577,493–47,579,738 | 66.0 kb | Distal (>10kb) Multiome | 446 | |
| chr3:47,781,220–47,782,492 | 268.6 kb | Distal (>10kb) Multiome | 965 | |
| chr3:47,802,571–47,803,701 | 289.8 kb | Distal (>10kb) Multiome HiCAR | 820 |
Genomic view of the ELP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.