The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for ELP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,849,802–35,850,882 | 279.7 kb | Distal (>10kb) Multiome | 177 | |
| chr18:35,851,060–35,852,119 | 278.3 kb | Distal (>10kb) Multiome | 244 | |
| chr18:35,949,718–35,950,700 | 179.6 kb | Distal (>10kb) Multiome | 420 | |
| chr18:35,971,798–35,973,006 | 157.4 kb | Distal (>10kb) Multiome | 1056 | |
| chr18:36,066,875–36,067,975 | 62.3 kb | Distal (>10kb) Multiome | 832 | |
| chr18:36,128,266–36,130,354 | 306 bp | At TSS Multiome | 1064 | |
| chr18:36,186,392–36,188,500 | 57.6 kb | Distal (>10kb) Multiome | 747 | |
| chr18:36,296,503–36,298,742 | 167.8 kb | Distal (>10kb) Multiome | 532 |
Genomic view of the ELP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.