In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for ELAVL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELAVL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELAVL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:23,819,272–23,820,091 | 1.4 kb | Proximal (<10kb) | 54 | |
| chr9:23,820,523–23,823,516 | 4.5 kb | Proximal (<10kb) Multiome | 435 | |
| chr9:23,824,327–23,825,607 | 2.8 kb | Proximal (<10kb) | 281 | |
| chr9:23,825,805–23,826,813 | 98 bp | At TSS Multiome | 399 | |
| chr9:23,829,710–23,830,388 | 8.2 kb | Proximal (<10kb) | 135 | |
| chr9:23,831,041–23,832,185 | 5.2 kb | Proximal (<10kb) Multiome | 207 | |
| chr9:23,849,486–23,851,834 | 24.8 kb | Distal (>10kb) Multiome | 433 |
Genomic view of the ELAVL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.