Predicted to enable BMP receptor binding activity. Predicted to be involved in negative regulation of nervous system development; positive regulation of BMP signaling pathway; and positive regulation of epidermis development. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ELAPOR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELAPOR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELAPOR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:86,643,462–86,645,461 | 415.7 kb | Distal (>10kb) Multiome | 398 | |
| chr7:86,685,174–86,685,929 | 374.1 kb | Distal (>10kb) Multiome | 121 | |
| chr7:86,964,698–86,966,215 | 94.5 kb | Distal (>10kb) Multiome | 164 | |
| chr7:87,058,811–87,060,346 | 88 bp | At TSS Multiome | 675 | |
| chr7:87,128,891–87,130,142 | 69.6 kb | Distal (>10kb) Multiome | 290 | |
| chr7:87,151,812–87,153,325 | 92.8 kb | Distal (>10kb) Multiome | 1045 | |
| chr7:87,218,879–87,221,122 | 160.9 kb | Distal (>10kb) Multiome | 908 | |
| chr7:87,344,909–87,346,229 | 285.9 kb | Distal (>10kb) Multiome | 838 |
Genomic view of the ELAPOR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.