EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for EIF4E3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4E3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4E3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:71,581,323–71,584,986 | 172.8 kb | Distal (>10kb) Multiome | 948 | |
| chr3:71,724,579–71,725,985 | 29.4 kb | Distal (>10kb) Multiome | 430 | |
| chr3:71,729,677–71,730,351 | 24.8 kb | Distal (>10kb) Multiome | 234 | |
| chr3:71,753,029–71,755,146 | 851 bp | At TSS Multiome | 301 | |
| chr3:71,784,668–71,785,699 | 30.4 kb | Distal (>10kb) Multiome | 273 | |
| chr3:71,875,256–71,876,589 | 120.9 kb | Distal (>10kb) Multiome | 430 | |
| chr3:71,925,496–71,926,501 | 171.7 kb | Distal (>10kb) Multiome | 136 | |
| chr3:72,028,296–72,029,097 | 274.1 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the EIF4E3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.