EIF4A1
eukaryotic translation initiation factor 4A1 | DDX2A, EIF-4A, EIF4A

Enables double-stranded RNA binding activity and translation initiation factor activity. Involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.35
Biological processes 32 terms
ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)RNA binding (GO:0003723)RNA cap binding (GO:0000339)RNA helicase activity (GO:0003724)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic stress granule (GO:0010494)cytoplasmic translational initiation (GO:0002183)cytoplasmic translational initiation (GO:0002183)cytosol (GO:0005829)double-stranded RNA binding (GO:0003725)eukaryotic translation initiation factor 4F complex (GO:0016281)eukaryotic translation initiation factor 4F complex (GO:0016281)extracellular exosome (GO:0070062)helicase activity (GO:0004386)helicase activity (GO:0004386)mRNA binding (GO:0003729)membrane (GO:0016020)nuclear stress granule (GO:0097165)nucleic acid binding (GO:0003676)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)translation factor activity, RNA binding (GO:0008135)translation initiation factor activity (GO:0003743)translation initiation factor activity (GO:0003743)translational initiation (GO:0006413)
Expression (TPM)
EIF4A1 — as a Regulated Gene

TFs regulating EIF4A1 0 TFs

Transcription factors with Perturb-seq knockdown data for EIF4A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to EIF4A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,280,161–7,282,555 291.2 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 278.1 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 276.3 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 265.4 kb Distal (>10kb) Multiome 896
chr17:7,314,722–7,315,725 257.5 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 243.3 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 222.6 kb Distal (>10kb) Multiome HiCAR 414
chr17:7,351,208–7,352,575 220.8 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 216.6 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 188.6 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 178.2 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 168.5 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 135.7 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 134.5 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 132.1 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 127.3 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 117.2 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 93.3 kb Distal (>10kb) Multiome 574
chr17:7,483,139–7,485,576 88.4 kb Distal (>10kb) Multiome 1156
chr17:7,548,693–7,549,285 23.8 kb Distal (>10kb) Multiome 387
chr17:7,560,249–7,562,536 10.9 kb Distal (>10kb) Multiome 759
chr17:7,572,039–7,574,418 1.1 kb Proximal (<10kb) Multiome 1071
chr17:7,579,018–7,579,876 6.6 kb Proximal (<10kb) Multiome 844
chr17:7,583,063–7,584,547 11.0 kb Distal (>10kb) Multiome 921
chr17:7,588,871–7,590,534 17.3 kb Distal (>10kb) Multiome 319
chr17:7,614,065–7,615,780 42.3 kb Distal (>10kb) Multiome 708
chr17:7,627,090–7,628,247 55.0 kb Distal (>10kb) Multiome 712
chr17:7,650,010–7,652,127 78.0 kb Distal (>10kb) Multiome 467
chr17:7,685,876–7,686,907 113.5 kb Distal (>10kb) Multiome 765
chr17:7,687,214–7,687,777 114.7 kb Distal (>10kb) Multiome 710
chr17:7,687,867–7,688,863 115.5 kb Distal (>10kb) Multiome 700
chr17:7,703,383–7,703,975 130.8 kb Distal (>10kb) Multiome 141
chr17:7,704,799–7,705,590 132.3 kb Distal (>10kb) Multiome 325
chr17:7,716,832–7,717,983 144.5 kb Distal (>10kb) Multiome 759
chr17:7,833,417–7,837,960 262.8 kb Distal (>10kb) Multiome 1160
chr17:7,841,438–7,843,228 269.4 kb Distal (>10kb) Multiome 861
chr17:7,843,355–7,844,130 270.8 kb Distal (>10kb) Multiome 614
chr17:7,844,349–7,845,186 272.1 kb Distal (>10kb) Multiome 617
chr17:7,851,538–7,852,239 279.0 kb Distal (>10kb) Multiome 531
chr17:7,856,600–7,858,747 284.7 kb Distal (>10kb) Multiome 942

Genome Browser

Genomic view of the EIF4A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,270,161 – 7,868,747
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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