This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for EIF3J. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF3J upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF3J, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:44,288,537–44,289,473 | 248.4 kb | Distal (>10kb) Multiome | 806 | |
| chr15:44,426,579–44,428,620 | 109.9 kb | Distal (>10kb) Multiome | 941 | |
| chr15:44,536,026–44,537,829 | 140 bp | At TSS Multiome | 958 | |
| chr15:44,663,054–44,664,141 | 126.6 kb | Distal (>10kb) Multiome | 1030 | |
| chr15:44,683,274–44,683,762 | 146.3 kb | Distal (>10kb) Multiome | 211 | |
| chr15:44,710,930–44,712,219 | 174.4 kb | Distal (>10kb) Multiome | 782 | |
| chr15:44,728,448–44,729,627 | 191.9 kb | Distal (>10kb) Multiome | 787 |
Genomic view of the EIF3J locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.