This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for EIF3G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF3G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF3G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,827,304–9,828,194 | 292.1 kb | Distal (>10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 284.8 kb | Distal (>10kb) Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 206.2 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 205.1 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,933,993–9,934,841 | 185.5 kb | Distal (>10kb) Multiome HiCAR | 425 | |
| chr19:9,935,627–9,937,234 | 183.4 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr19:10,027,570–10,028,022 | 92.1 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 33.6 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 23.6 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 13.6 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 6.7 kb | Proximal (<10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 55 bp | At TSS Multiome | 818 | |
| chr19:10,194,229–10,195,372 | 75.0 kb | Distal (>10kb) Multiome | 939 | |
| chr19:10,230,671–10,231,665 | 111.5 kb | Distal (>10kb) Multiome | 595 | |
| chr19:10,251,723–10,252,663 | 132.1 kb | Distal (>10kb) Multiome | 969 | |
| chr19:10,269,513–10,270,051 | 149.7 kb | Distal (>10kb) Multiome | 523 | |
| chr19:10,270,913–10,271,370 | 151.3 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,286,849–10,287,511 | 167.2 kb | Distal (>10kb) Multiome | 621 | |
| chr19:10,288,709–10,290,833 | 169.0 kb | Distal (>10kb) Multiome | 688 | |
| chr19:10,292,085–10,293,198 | 172.6 kb | Distal (>10kb) Multiome | 441 | |
| chr19:10,315,359–10,316,478 | 196.0 kb | Distal (>10kb) Multiome | 830 | |
| chr19:10,332,816–10,334,107 | 213.6 kb | Distal (>10kb) Multiome | 882 | |
| chr19:10,334,573–10,335,642 | 215.1 kb | Distal (>10kb) Multiome | 584 | |
| chr19:10,352,359–10,354,435 | 232.8 kb | Distal (>10kb) Multiome | 447 | |
| chr19:10,380,209–10,381,218 | 260.8 kb | Distal (>10kb) Multiome | 874 | |
| chr19:10,403,282–10,404,914 | 283.8 kb | Distal (>10kb) Multiome | 794 | |
| chr19:10,416,245–10,417,312 | 296.8 kb | Distal (>10kb) Multiome | 988 | |
| chr19:10,417,499–10,421,409 | 300.4 kb | Distal (>10kb) Multiome | 801 |
Genomic view of the EIF3G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.