Enables identical protein binding activity and metal-dependent deubiquitinase activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive intellectual developmental disorder 67. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EIF3F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF3F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF3F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:7,905,555–7,906,470 | 81.2 kb | Distal (>10kb) Multiome HiCAR | 98 | |
| chr11:7,909,636–7,910,173 | 77.6 kb | Distal (>10kb) Multiome HiCAR | 37 | |
| chr11:7,986,569–7,987,645 | 166 bp | At TSS Multiome | 879 | |
| chr11:8,018,776–8,020,008 | 31.9 kb | Distal (>10kb) Multiome | 365 | |
| chr11:8,032,871–8,033,670 | 46.0 kb | Distal (>10kb) Multiome | 307 | |
| chr11:8,080,656–8,082,014 | 93.9 kb | Distal (>10kb) Multiome | 370 | |
| chr11:8,168,430–8,169,450 | 181.5 kb | Distal (>10kb) Multiome | 329 | |
| chr11:8,192,451–8,193,309 | 205.5 kb | Distal (>10kb) Multiome | 185 | |
| chr11:8,261,997–8,263,550 | 275.5 kb | Distal (>10kb) Multiome | 309 | |
| chr11:8,267,870–8,269,102 | 281.2 kb | Distal (>10kb) Multiome | 247 |
Genomic view of the EIF3F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.