The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for EIF2S3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF2S3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF2S3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:23,782,718–23,783,632 | 271.9 kb | Distal (>10kb) Multiome | 741 | |
| chrX:23,907,232–23,908,257 | 147.1 kb | Distal (>10kb) Multiome | 770 | |
| chrX:24,024,718–24,026,097 | 29.5 kb | Distal (>10kb) Multiome | 765 | |
| chrX:24,054,185–24,055,227 | 322 bp | At TSS Multiome | 763 | |
| chrX:24,149,214–24,150,721 | 95.3 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the EIF2S3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.