Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for EIF2S2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF2S2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF2S2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:33,992,591–33,994,776 | 118.8 kb | Distal (>10kb) Multiome | 1067 | |
| chr20:34,111,659–34,113,028 | 61 bp | At TSS Multiome | 1069 | |
| chr20:34,302,649–34,303,619 | 191.0 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:34,311,332–34,311,914 | 199.3 kb | Distal (>10kb) Multiome | 577 | |
| chr20:34,312,547–34,313,008 | 200.6 kb | Distal (>10kb) Multiome | 740 | |
| chr20:34,345,865–34,346,371 | 233.9 kb | Distal (>10kb) Multiome | 61 | |
| chr20:34,362,888–34,363,977 | 251.0 kb | Distal (>10kb) Multiome | 858 |
Genomic view of the EIF2S2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.